Masquelier’s OPC

Not to be confused with pedestrian grape seed and pine bark extracts (Which are non specific names and have no patents), Masquelier’s® OPC is derived from French maritime pine bark as well as vitis venisera (grape seed) which contains different monomers; catechins, and epicatechins–a momimer unique to venis venisera grape seed, where as in pine bark you have catechins and taxifolin–a monomer unique to opc’s extracted from maritime pine bark.

Completely dissolvable in water, Masquelier’s® OPC is an isolate of living molecules and is the only extract from grape seed/pine bark validated by the French Ministry of Health. No other extract of grape seed and or pine bark has been so thoroughly studied, tested, and proven in clinical trials.

The health benefits of the essence that which lives in the skin surrounding the grape seed (the very thin membrane or skin surrounding the grape seed itself–Oligomeric proantho-cyanidins pronounced “Sigh-an-ah-dins”) are so numerous and significant, that one who enumerates them runs the risk of sounding hyperbolic. Here is a brief list of what Masquelier’s® OPC can do:

Improve skin elasticity by enhancing the ability of collagen to repair itself.
◦ Protects existing collagen stored in connective tissue and promote the production of collagen protein in the vascular wall, increasing the strength and elasticity of blood vessels, protecting the entire circulatory system against rupture, leakage, and degenerative process.
◦ Relieves functional problems of varicose veins
◦ Help prevent capillary bleeding
◦ Lowers LDL cholesterol levels, reducing the risk of cardiovascular disease
◦ Reduces the tendency toward diabetic retinopathy (leaky damaged blood vessels in the retina)
◦ Improves red-blood-cell-membrane flexibility
◦ Inhibits swelling (edema) and inflammation
◦ Free radical scavenging

MASQUELIER’s® OPCs enhances vascular strength and elasticity, thus improving overall circulatory efficiency. This is achieved by the ability of this phytonutrient to bind collagen and elastin that are key proteins in blood vessel walls, and to promote collagen synthesis and inhibit degradation of collagen and elastin. Through its beneficial effects on vasculature, MASQUELIER’s® OPCs promotes better vein tone and elasticity, enabling better return of blood to the heart via veins, and thus relieves functional problems of venous insufficiency and varicose veins.

Click here to read more about OPC and The Cardiovascular System

Masquelier® OPCs’ Method of ActionA superior antioxidant, Masquelier’s® unique combination of flavnoids modulates nitric oxide production allowing o ur blood to flow better, our immune system to work better, and our joints to hurt less. Masquelier’s® is also especially good at neutralizing hydroxyl and superoxide radical s, singlet oxygen, and the dangerous chemical peroxynitrate.

Peroxynitrate is hazardous in that it oxidizes with anything: fats, proteins, DNA,… which leads to arthritis, diabetes, stroke, septic shock, chronic inflammation, and atherosclerosis. Masquelier’s® has no known drug interactions. For maximum absorption it should be taken between meals or on an empty stomach with a large glass of water.

Each bottle contains 180 one-hundred-milligram capsules of pure undiluted** Masquelier’s® OPC. representing approximately a three-month supply. ESA Study Charts ESA Study and Charts

*MASQUELIER’S® is a trademark owned by INC
**Some companies capitalize on the Masquelier’s® name by blending in a small amount of this extract into their predominantly grape seed formulations. Buy authentic Masquelier’s Grape Seed extract

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Professor Jack Arthur Masquelier (1922-2009)

Legendary and amiable French scientist Jack Masquelier, one of the great pioneers in the fields of photochemistry and human health, died Tuesday, 24 February, in Bordeaux, France.

Over sixty years ago, in July 1948, Jack Masquelier published his doctorate thesis upon the successful isolation and chemical description of the phyto-nutrient we know today as oligomeric proanthocyanidins or OPCs. That same year he filed a patent for the industrial method of producing the first botanical product based on OPCs.

Based on Dr. Masquelier’s groundbreaking and always innovative role in the research, isolation, identification and therapeutic and dietary applications of OPCs, two botanical products followed. In the 1960s, a botanical medicine based on OPCs isolated from Pinus maritima bark saw the light of day, followed ten years later by an OPCs-based medicinal product manufactured from Vitis vinifera seeds. In France, these medicinal products are still sold today. During the 1980s these complex, but well characterized phytonutrients, were introduced on the natural products market. Today, Masquelier’s OPCs are sold around the world as dietary supplements.

The postwar period, when Masquelier began his research, was marked by a surge in interest in flavanols, the group of bio actives to which proanthocyandins belong. In 1951, Australian scientist W.G.C. Forsyth first isolated flavanols from fresh coco-beans. In that same year, using Masquelier’s OPCs, the English phytochemist E.C. Bate-Smith, working at Cambridge (UK), developed and first described a coloration method to detect the presence of proanthocyanidins in plant materials.

Masquelier’s scientific work was seminal in the early development of two areas of science: phytochemistry and human health. Finding that the nomenclature used in the fields of phytochemistry and botany could easily lead to confusion and imprecision when applied in the field of dietary and pharmaceutical products, Masquelier, together with his lifetime friend and colleague Dr. Jean Michaud, focused on, and succeeded in the characterization of OPCs-based products in conformity with nutritional and pharmaceutical standards, thus fitting for the field of human health.

Through tireless scientific investigation, Dr. Masquelier revealed the numerous health benefits of OPCs. The key early finding of Dr. Masquelier was that OPCs strengthen and protect blood vessels and vascular function, so essential for the function of every organ in the body. This set in motion a series of independent clinical studies by several other scientists that sustained Dr. Masquelier’s findings and provided conclusive support for the use of Masquelier’s OPCs-compounds in the French vasculo-protective medicines.

In 1985, Dr. Masquelier was able to further explain the intense and instant positive effects that OPCs have on the human body when he discovered that OPCs neutralizes free radicals, the common cause of seemingly unrelated degenerative conditions and early onset of age-associated changes in the body. He found that OPCs are powerful antioxidants and are unique in their ability to work in both aqueous and lipid phase to provide superior antioxidant support.

All of Dr. Jack Masquelier’s discoveries have greatly influenced human health worldwide, and have gained great significance in this era, when life expectancy has increased while accompanied by an equally dramatic increase in cardiovascular and other degenerative diseases. His products have grown in relevance in a world that has fundamentally changed since their discovery.

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How Masquelier Coined the Word Pycnogenols

In his 1979 article, Masquelier proposes that this group of flavanols be designated as “pycnogenols.” He coined the word on the basis of the fact that flavanols have this natural and spontaneous tendency to “thicken,” to condense. The Greek “pycno” means “thick,” the “gen” parts stand for generate and the “ol” suffix comes from flavanol.

While preparing behind his typewriter for his “set-the record straight” article, Masquelier didn’t have a clue that the name he was coining would become the subject of heated legal trademark battles. Being a scientist and not a trademark lawyer, Masquelier never realizes that his “pycnogenols” could rise from the generic way he used it at first, to a real trademark. Whatever the legal status of the word, it was Masquelier’s intention that the name be used to designate the totality of the extract, that is obtained from various vegetal sources by means of the use of his patented methods of extraction.

The reason why the original word is pycnogenols (plural) is because Masquelier wanted to indicate that his extracts contain the monomers, the dimmers and the trimmers, each of them being a “pycnogenol.”

The commercial exploitation of Masquelier’s “pycnogenols” extracts had been put in the hands of a company by the name of Centre d’Experimentation Pharmaceutique (CEP), situated in Leognan (France). Masquelier was partner in CEP, until in April 1994, he and his 3 partners sold all of CEP’s shares. CEP changed it seat of business to Valbonne (France). When the use of the name pycnogenols as a trademark surfaced as an issue, Masquelier decided that, since he was the inventor and owner of the name, all registrations of “Pycnogenols” as a trademark would remain the responsibility of CEP/SCERPA. So, in 1989, he registered the name “Pycnogenols” as trademark for the first time. The registration is French, No. 1522228 and was done in the name of Masquelier’s Societe Civile pour l’Expansion de la Recherche en Phytochimie Appliquee” (SCERPA). When Masquelier sold his shares in CEP he also sold this trademark registration. Also, Masquelier wanted to maintain control over “Pycnogenols” since he wanted to prevent the use of the trademark from being limited to one particular extract. It has been his intention that whatever the vegetal source, the name would always apply, provided that the extraction is done according to his method. Unfortunately for Masquelier, CEP and SCERPA the good intentions and good faith have not been sufficient tools to protect their intellectual property. “Pycnogenol” has been deposited and registered as a trademark in many countries. In some countries this was done with Masquelier’s explicit consent. But in other countries the registration was done by parties unknown to him or which he had explicitly forbidden to do so. What remains is some bitterness on his part, especially because he feels that pycnogenols without the “s” is a misnomer. Chemically speaking, the name should have been “Pycnogenols”… Buy three get one free.

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1994 Masquelier recalls meetings With Szent-Gyorgyi the Father of Vitamin C

In December 1994, an interview with Jack Masquelier was recorded in the study of his summer house in Martillac (France).  Szent-Gyorgyi was a Hungarian physiologist who won the Nobel Prize in Physiology or Medicine in 1937. He is credited with discovering vitamin C and the components and reactions of the citric acid cycle. Mr. Masquelier is Professor Emeritus of the University of Bordeaux. The interview took place during the production of the video tape that accompanies the revised the 2nd edition of Masquelier’s great book on the discovery of OPC. During that conversation, Professor Masquelier, who may well be credited for having solved the “vitamin C co-factor” part of the story, recalled his meetings with Szent-Gyorgyi. “I met him at Oxford in 1947, at the first international Physiology Congress that took place after the Second World War. He has been to Bordeaux as well. He was awarded an honorary degree from our university. He was very interested in my work at the time. I did research on a substance had a considerable effect on the capillary resistance (permeability) in guinea pigs. Szent-Gyorgyi had come to see me in my laboratory. He said, ‘But Mr. Masquelier, are you still interested in that? Don’t you know that in the U.S. no one believes in bioflavonoids (citrin) anymore?’ So even he, the father of vitamin P, had abandoned this track, because he hadn’t been able to explain why he would sometimes get a good result and sometimes a bad result.”

Masquelier vividly remembers how to unsolved puzzle had left his Hungarian colleague with a “feeling of regret. Szent-Gyorgyi,” Masquelier recalls, “liked to joke about his two discoveries (vitamin C and citrin). He received the Nobel Prize for his work on vitamin C, whereas for him vitamin C wasn’t really a vitamin but merely a nutritional element. Szent-Gyorgyi realized that the required daily intake of ascorbic acid was rather high, whereas by definition vitamins are substance of which only a few milligrams a day are required. So, Szent-Gyorgyi received the Nobel Prize for his discovery of a vitamin, but he didn’t like it to be called a vitamin. And later, after he had isolated citrin and named it vitamin P, they refused to call his vitamin P a vitamin because, as they put it, it was no possible to reproduce a state of citrin-avitaminosis. On various occasions, Szent-Gyorgyi told ‘It’s unbelievable. They have made me the father of vitamin C, while I wasn’t, and they have refused to make me the father of vitamin P, which I was.’ You know, there was always this feeling of regret, because he knew that both substances were needed to conquer scurvy.”

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OPC extraction. Masqueliers method Marking it with Carbon 14

Any company wanting to introduce a medicine or dietary supplement on the market will have to at least prove that the substance is biologically available and in what amounts. This is an absolute requisite for the simple and obvious reason that substances that, though swallowed, do not spread throughout the body are useless. When Masquelier’s research really took shape, it could safely be said that the extract produced with his method consistently showed the most superior vitamin P action compared with that of all the other flavanol and bioflavonoid extracts. But in spite of all the positive results gathered during all the years of research and experience, it still wasn’t possible to claim that these results were directly attributed to OPC.  It was never really sure if OPC could overstep the barriers of digestion in an unchanged or unaffected form. It could very well be that the effects on the vascular wall were realized by an unspecific fragment of the OPC molecule.

So when the French company Sanofi/Labaz decided to introduce Masquelier’s extract as a medicine to the market under the name of Endotelon, it still had to pass the great test. But, which of the available vegetal raw materials should one choose to perform the test with? Masquelier remembers, “I needed to check the bio-availability of OPC grape seed extract. In order to verify whether it is bio-available, I marked it with 14-carbon, rendering it radioactive. So, we had to grow the plant we wanted to obtain the OPC from in an artificial atmosphere with a high radioactive CO2 content. Through photosynthesis, all the elements in the plant which contain carbon exchange their ordinary carbon for radioactive carbon. I used vines to obtain radioactive OPC by keeping the vines in the phytotron for 45 days. I was then able to experiment with the bioavailability by administering the radioactive OPC to laboratory animals.” Buy Authentic Masquelier’s OPC. Buy three, get one free. Lowest price in the world.

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Oligomeric Proanthocyanidins are a very common component of many vegetables

Older trees have thicker bark.

THE VEGETAL SOURCES OF OPC

OPC exists in practically every plant and can be extracted from many vegetable sources. The study of 500 different types of plants demonstrates that flavanols are spread widely throughout the plant kingdom. They are found in ligneous sections (bark), in the fruit (peels and skin), in the groundnuts (skin), in the seeds (skin) and in the leaves and blossoms of woody plants (trees and shrubs). Masquelier developed extraction methods whereby OPC can be produced from virtually every plant. Still, the ways in which Masquelier has been striking an efficient balance between laboratory, scientific knowledge and the economical realities of agriculture and industry, show that one cannot just pick a plant that pleases the dreaming mind.

In terms of the availability and manageability of raw materials, it has become evident that pine bark and grape-seeds are reliable and industrially process able sources of OPC. Both sources give a high yield. We cannot rule out the effects of climate and since OPC is retrieved from “leftovers” (bark and seeds) one is also dependent on the methods of cultivation and harvesting. For the lumber and paper industry, pine trees are being chopped down earlier and earlier during their growth. Older trees have thicker bark than young trees, but they appear less and less in the forest. This can mean that in the long run pine bark might become a less feasible source for the extraction of OPC. Buy Masquelier’s OPC. Lowest price on the internet.

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Phyto Therapeutics: A multifaceted spectrum of plant extracts for survival

In order to survive, man has always made use of extracts. In the field of nutrition, the extraction method is used to obtain a longer-lasting, more digestible or tastier product. The removal of water from a food already means we are making an extract. Dried food can be more easily stored and transported. In earlier times, this was of essential importance in order to survive.

However, as we have seen in the case of OPC, we can also go in reverse and use water as a means of extraction. Plants that contain vital elements but whose natural form we cannot or do not want to use, can be “brewed” (extracted) in water and this is how we get tea, beer or coffee.

Wine we obtain by squeezing the juice out of grapes and letting the juice mature. We have already noted that the bioflavanols in all these cases have a preserving and product-improving effect.

We only have to go one step further and we begin to deal with plant extracts in the scope of medicine. Ginkgo biloba leaves, the ginseng root, lime blossom, grapes-seeds and the barks of pine and willow are just a few examples of plants or plants or parts of plants that provide a rich, multifaceted spectrum of extracts that have for centuries been used for therapeutic or preventive purposes. We have empirically known for a long time that the effects of these phytotherapeutic products on health are. There have been many sizable books written about this subject. Through modern methods of isolation and analysis, we are in a better position to know which active substances give so many extracts and foodstuffs their health value. With these active substances “in hand” we are able to dose and target them in a truly orthomolecular fashion. The right molecules, in the right dosages, in the right places of our body.

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Every Grape Vine Has its Own Fingerprint

There are practical sides to the fact that Western culture is so interested in searching for the fragments of the whole. Molecules such as bioflavanols found in grape seed extracts are produced in the plant with the help of enzymes. Every enzyme controls a particular biochemical reaction. Every type plant (species) has its own specific “set” of enzymes and therefore every plant produces its own “set” of flavanols. These “sets” are so specific that they are referred to as fingerprints. One can recognize the plant by its bioflavanols make-up.

Knowing these fingerprints by means of chemical analysis comes in handy, not only in the manufacturing of specific medicines and dietary supplements, but also in the quality control of our food. Within the framework of flavanols, this applies for instance to the art of  wine-making, since every grapevine has its own fingerprint. Therefore, it is possible to determine if the wine in the bottle is in fact the wine mentioned on the label. This is how the legitimate wine business protects itself from imitation and fraud. The same goes for grape seed extracts. Food industry and governmental agencies use such refined “fingerprint” techniques to establish whether the product’s contents really match label contents. Buy Authentic Masquelier’s OPC extract buy three get one free plus free shipping and handling. Unparalleled value .

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Masquelier’s OPC Is Unmatchable with Improved Chromatographic Method

In 1955, armed with his growing knowledge about extraction and analysis of flavanols, Masquelier demonstrated that OPC is a major constituent of red wine. With an improved chromatographic method, he demonstrated that wine contained the same OPC molecules found in and isolated from the skins of peanuts and pine bark.

Masquelier in 1955

Slowly but surely a complete picture developed with respect to the structure and nature of this extremely effective substance. It is this substance that gives the vitamin P effect to plants and food. As we shall see later on, it was demonstrated that this constituent was many times more effective than rutin. It became more and more certain that from all the vegetable polyphenols, the flavanols are unmatchable in vitamin P action. They are far more superior than the bioflavonoids.

Without exaggerating, it may be said that bioflavanols always plan an influential role where plants, plant extracts, foods and remedies are used for health-promoting effects. Whether we are dealing with hawthorn, mistletoe, red wine, green tea or Ginkgo biloba, over and over again we are confronted with the bioflavanols as the superior, active element.

Step by step, Masquelier and his colleagues researched, finding full confirmation and explanation of Jacques Cartier’s Indian tale. They realized that the bark of the Canadian Anneda tree must have been replete with bioflavanols and, in addition, the needles must have contained vitamin C. A better anti-scurvy remedy probably doesn’t exist. Being close to Nature, the American Indians had known the remedy ages before Cartier set foot on North American ground.

We in Western culture have always sought proof of “Indian tales” per the scientific methods we developed, even though in practice such Folk Medicine remedies are serious business. For that matter, the Indians are not the only ones familiar with natural remedies before they were scientifically proven. Folk medicine and herbal extracts are found all over the world. In fact, they are about as old as the world itself. Click here to buy Masquelier’s grape seed extract.

 

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Isolating the constituents of OPC is a waste of time. It impairs efficacy. They are essential components of the brick house

Masquelier writes: “To me it seems undesirable to cut the extract up into small parts. What would you want to do with them? We are not at all certain that each of the individual components could be stabilized. Let me remind you of the fact that one of my colleagues, Professor Bourzeix, with whom I’ve often worked together, and who works on oligomeres at the  INRA, the National Agronomical Research Institute in Narbonne, very patiently cut the extract up into ‘slices’ and lyophilized those, in order to protect them against oxidization and aging. He wanted to study their individual analytical and physiological behavior. This took a lot of time. It took at least two years to separate the components. And when he studied the first components to see how they had developed, analysis showed that they had changed completely. These components should only have resulted in a single chromatographic stain like any pure substance, but instead they produced two or three chromatographic stains. So when you try to isolate the constituents of OPC, albeit for a worthy cause, you are wasting your time.

FURTHER SEPARATION IMPAIRS EFFICACY Masquelier writes: “By themselves, these substances are not stable. For example: if you isolate the catechins from my extract, they once again become pure catechins, which are not soluble and unstable. You might isolate this dimer or that trimer and so on, but it would be very time-consuming and expensive. And you would end up with a substance which is less soluble and less stable. So this may be interesting from a scientific point of view, but it is disastrous from an industrial point of view.”

Masquelier’s OPC observes the highest standard with regard to the treatment of the plant will the result be favorable. Everything depends on the quality of the solvents, the filtering, the centrifugation, the temperature, the freshness of the raw material used etc . . . Every kilo of biomass is analyzed before it is put out on the market, ensuring that the product meets pharmaceutical medicinal standards. Careful application of Masquelier’s method renders a substance that contains a large amount of oligomeric proanthocyanidins. There are other ingredients as well, more specifically the water-soluble tannins (polymers) and catechins (monomers). Certainly, at the core of the range of extracted polyphenols are the oligomeric proanthocyanidins.Masquelier writes: “In other words, to explain what the plant gives us after the extraction has been applied, what we see is similar to what we find lying around a brick walls, with unused bricks lying all around it. You could say that catechins are like those bricks, they are building elements. By putting together bricks you build walls, and those walls together form a house. OPC is the house, the oligomeres, dimers and trimers are the walls. And the catechins are the bricks that are left over. But they no longer serve a purpose. We leave them where they are, because they are not toxic.” Buy Masqueliers pure OPC

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