Piracetam is a cerebral function regulating supplement proven to enhance cognition as it attenuates brain aging. A cyclic derivative of GABA, Piracetam is commonly prescribed in Europe for a variety of conditions (see below). It is considered by the scientific community to be one of the most toxicologically safe supplements ever developed.  So much so, it is used to prevent or reverse the toxic action of a broad array of chemicals and conditions. Though not a direct anti-depressant, piracetam is considered a excellent adjunct to most anti-depressant protocols.

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Piracetam Benefits

• Increases the brains ability to process information and think clearly.
• Piracetam reverses the effects of brain aging.
• Piracetam has been used successfully to treat alcoholisrn/ alcohol withdrawal syndrome and alcohol induced brain damange.
• Piracetam slows deterioration, in "senile involution" dementia and Alzheimer’s disease.
• Piracetam facilitates recovery from aphasia (speech impairment) after stroke.
• Piracetam supports the restoration of various functions (use of limbs, speech, EEC, slate of consciousness) in people suffering from acute and chronic cerebral ischemia (decreased brain blood flow).
• Piracetam supports alertness, co-operation, socialization, and IQ in elderly psychiatric patients suffering from "mild diffuse cerebral impairment.
• Piracetam reduced the severity and occurrence of major symptoms of "post-concussional syndrome," such as headache, vertigo, fatigue and decreased alertness
• Piracetam has been used to inhibit sickle cell anemia, both clinically and experimentally.
• Piracetam increases performance on a variety of cognitive tasks among dyslexic children.
• Piracetam also has a significant antioxidant effect.
• Piracetam is sometimes prescribed as an aid to muscle or dexterity training, particularly in cases of dysgraphia and dyspraxia. There has not been a specific study as to whether it is beneficial in this aspect. Vinpocetine another nootropic with which piracetam is indirectly synergistic, is confirmed to help with these conditions to a certain degree.
• Piracetam Works to reduce abnormal blood clots
• Piracetum is also a powerful anti thrombotic and natural anti platelet aggregator.

Mechanisms of action

The mechanisms of action of Piracetam are quite broad. Piracetam is understood to work by stimulating the cerebral cortex as well as by increasing the rate of metabolism and the energy levels of neurons. It possibly facilitates movement of information between the brain's two hemispheres via the corpus callosum, and improves the function of the neurotransmitter acetylcholine via muscarinic cholinergic (ACh) receptors which are implicated in memory processes. Furthermore, Piracetam may have an effect on NMDA glutamate receptors which are involved with learning and memory processes. Finally, Piracetam may exert its global effect on brain neurotransmission via modulation of ion channels (ie. Ca2+, K+).

History

Piracetam was first synthesized in 1964 by scientists at the Belgian pharmaceutical company UCB led by Dr Corneliu E. Giurgea. The drug was the first of the so-called nootropics ("smart drugs" or "cognitive enhancers"), that is, substances which purportedly enhance mental performance. The term nootropic was coined by Giurgea. Nootropil was launched clinically by UCB in the early 1970s and remains an important product of that company in Europe.

Dosage

Piracetam is usually supplied in 800 mg tablets or capsules. The recommended dosage varies based on the indication, usually ranging from 1.6-9.6 grams daily (2-12 pills daily). Some people report faster results when taking 1-2 pills every hour for 4-6 hours or taking 4-8 pills at once for the first few days to notice an effect.

It has been studied up to 45 grams daily without major side effects.

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