Photograph of Thiamine under the microscope

Thiamine helps to maintain normal function of the nervous system, muscles, and heart, and is necessary for normal growth and development.

Symptoms of thiamine deficiency are loss of appetite, fatigue, nausea, vomiting, and mental problems.

Reduced blood levels of thiamin have been reported in individuals with seizure disorders (epilepsy) taking the anticonvulsant phenytoin, for long periods of time. 5-Fluorouracil, a drug used in cancer therapy, inhibits the phosphorylation of thiamin to thiamin pyrophosphate (TPP), especially furosemide (Lasix), may increase the risk of thiamin deficiency in individuals with marginal thiamin intake due to increased urinary excretion of thiamin.

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