London: Cameron Diaz admits she accepted the offer to appear in movie `Knight and Day` to battle the grief of her father`s death.

The 37-year-old actress is paired opposite Hollywood hunk Tom Cruise in the James Mangold`s directorial venture. Diaz was devastated when her father Emilio died of pneumonia in April 2008 during the filming of `My Sister`s Keeper`. She admits that she took the role opposite Cruise because she was desperate to have some "fun" afterwards, Contact music reported.

Scientists have for the first time obtained evidence for the link between cholesterol-lowering drugs and depression in people taking these drugs to prevent heart attack.
They have found that cholesterol-lowering drug may affect the activity of a brain chemical that controls mood and behavior and thereby trigger anxiety and depression.

Cholesterol, a wax like substance, is the main culprit in heart disease. Although the body needs it, a high level of serum cholesterol causes blockage of coronary arteries thereby reducing blood circulation to the heart muscles leading to heart attack. A class of drugs called 'statins' which lower the cholesterol level -- by inhibiting a key enzyme responsible for its biosynthesis in the body - are the highest selling drugs in the global market and in clinical history with an estimated sale of 25 billion USD annually. They are extensively used as oral drugs to treat "hypercholesterolemia." Although they are very effective in reducing cholesterol levels in humans, there is a growing concern that chronic use of statins causes depression and anxiety in patients. "In the last few years, a number of publications in medical journals have reported apparent symptoms of anxiety and major depression in patients upon long-term statin administration," says Amitabha Chattopadhyay at the Centre for Cellular and Molecular Biology in Hyderabad.