As a long term user of your brand of St Johns Wort for, what I presume is mild constitutional depression ( as opposed to a depression with identifiable external cause ), I am happy to report I no longer suffer from this painful condition. I became aware of a general improvement in mood and energy some four to six weeks into the treatment at the standard dose of one tablet three times daily. I have experienced no untoward side effects during some eight years of use, nor did I notice a decrease in effectiveness. As a physician I was unwilling to consider such “natural” remedy until a friend has shown me the appropriate literature, having read it I decided to try – I am glad I did. I hasten to add the medication is not recommended for severe, possible suicidal, depression.